Duromine overview

With a lack of medical research and reported side effects, is Duromine a safe phentermine alternative?

duromineDuromine is a controlled C5 drug, available on prescription in Australia and New Zealand. Its generic name is phentermine and is licensed to be used for the short term treatment of obesity.

Manufactured and distributed by iNova Pharmaceuticals, in 2002 the European Commission withdrew the license for the distribution of Duromine, followed by the FDA in the US in 2010 due to the lack of medical research showing its efficacy and safety.

It is a slow release form of phentermine, its resin coating means the drug dissolves slowly in the bloodstream so the effects last all day. Duromine is prescribed as part of a weight management plan to instigate rapid, considerable weight loss.

Forms and Dosage

Duromine is available in three strengths in Australia, 15mg, 30mg and 40mg and just the two lower strengths in New Zealand. In capsule form the 15mg capsules are grey and green with ‘Duromine 15’ marked on them; the 30mg are grey and reddish brown marked ‘Duromine 30’; and the 40mg are grey and orange and marked ‘Duromine 40.’

All Duromine capsules are available in packs of 30s or packs of 7, and are licensed to be used for a maximum of 12 weeks, but the average course of treatment is between 3-6 weeks. One capsule should be taken daily before or within two hours of breakfast.

Conditions of Prescription

Duromine is licensed to be prescribed to treat obesity where the patient’s BMI is 27 or above and where there is a higher than normal medical risk of high cholesterol, blood pressure or diabetes. All other weight reduction options must have been fully explored before Duromine is prescribed, as it is seen as a last resort due to its risks to health and side effects.

Doctor-writing-a-prescriptionA full medical consultation based on the patient’s weight, age and medical condition will allow the doctor to determine which dose should be prescribed and for how long.

The benefits of the three strengths of Duromine allows the doctor to start the patient on the lower dose with fewer health risks and side effects, and only increase the strength if the patient is unresponsive.

The 40mg dose is the strongest prescription dose of phentermine anywhere in the world, and is intended for only the most severe cases of obesity where health and quality of life is severely compromised if significant, immediate weight loss is not achieved.

What does Duromine contain?

The active ingredient in Duromine is phentermine, part of the sympathomimetic amines class of drugs known as anoretics when used as a treatment of obesity. The resin coating means Duromine also contains lactose, liquid parafin, magnesium stearate, gelatine, titanium dioxide, iron oxide black and different colourings depending on the dose.

Duromine’s slow release formula means that the risks of side effects are slightly lower than with immediate release formulas, and is more suitable for those with stomach sensitivities or who have had adverse reactions to immediate release forms of phentermine.

Due to the addictiveness of phentermine, the lower dose poses a slightly lower risk of withdrawal, as phentermine is known to create withdrawal effects similar to some of its side effects when treatment is stopped.

How exactly does Duromine work?

Duromine, like all phentermine drugs, is intended to initiate rapid weight loss which can then be continued through a healthy eating and exercise plan.

The strong appetite suppressing qualities of Duromine mean that it can positively affect the eating habits in those where uncontrolled portion control has led to obesity and a sedentary lifestyle.

Even a short term reduction in appetite will help shrink the stomach, allowing for long term reduction in calorific intake, which when coupled with increased activity will lead to a positive cycle of weight loss and general improvements in health.

Duromine is not suitable for those with high blood pressure, heart disease, thyroid problems, alcohol or drug dependencies, psychiatric illness or glaucoma, pregnant and nursing women and the under 12s. Prescription from 12 onwards does allow Duromine to be used in severe cases of adolescent obesity.

Duromine can react with certain medications including migraine, cold remedies, thyroid hormones, high blood pressure medication, MAOI inhibiters and other medication for depression and mental illness. The medical consultation will assess the suitability of taking Duromine with any of these other medications.

Continued Medical Supervision

Once the length of treatment has been established, the doctor will monitor the patient to assess responsiveness to the drug and to alter the dose if necessary.

Side effects of Duromine are similar to other phentermine drugs (see the full list here) and include feeling more awake than usual, trouble sleeping, heart palpitations, raised blood pressure, chest pain, restlessness, extremes of mood, tiredness, nervousness, shaking, headache, dizziness, nausea, vomiting, diarrhoea, constipation, stomach cramps, difficulty breathing, fainting, swelling, skin rashes or impotence.

Any instances of these side effects need to be reported to the doctor as soon as possible. The course of treatment will be terminated in a controlled fashion to limit withdrawal symptoms; the higher the dose of Duromine the more control will need to be extended.

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Ionamin review

Ionamin Overview – Is Ionamin a safe short term solution for obesity?

ionamin-diet-pillsIonamin is a Schedule IV controlled substance available on prescription in the US for the short term treatment of obesity. Manufactured by Celltech Pharmaceuticals its generic name is phentermine resin complex.

Ionamin is a psychostimulant drug pharmaceutically similar to amphetamine which affects the central nervous system to suppress appetite, increase blood pressure, metabolism and energy levels.

Active ingredients are phentermine in either a 15 or 30mg dose, D&C Yellow No. 10, dibasic calcium phosphate, FD&C Yellow No. 6, gelatine, iron oxides (15 mg capsules only), lactose, magnesium stearate, titanium dioxide.

The American Vein and Aesthetics Institute reported that those taking Ionamin can expect to lose an average of 8-12lb per month. FDA licensing stipulates that like all phentermine drugs, due to their potential for abuse, Ionamin can only be prescribed for a limited amount of time to a maximum of 12 weeks.

The intention is that it will instigate significant weight loss which can then be developed through exercise and reduced calorific intake, the latter being easier due to the lower hunger levels established by Ionamin diet pills.

Forms and Dosage of Ionamin diet pills

woman-taking-ionaminIonamin is the only phentermine drug which is coated in a resin matrix giving it a sustained release formula, so the active ingredient is more slowly released into the blood stream.

There is no immediate release version of Ionamin as there is with Adipex P. The benefits of the slow release means there are fewer side effects, and the weight loss effects albeit milder, will last longer.

It has been suggested that differences can be quite subjective when comparing immediate and sustained release forms of phentermine.

However, Ionamin with its unique resin coating is more suitable for those with sensitive stomachs, or who have experienced reactions to immediate release forms of phentermine.

Ionamin diet pills come in two strengths, 15mg and 30mg; both come in bottles of 100 and 400. The 15mg is a yellow and grey capsule with ‘IONAMIN 15’ imprinted on it and the 30mg capsule is yellow and marked ‘IONAMIN 30.

Either dose should be taken once a day, one to two hours before breakfast on an empty stomach. They should be swallowed whole with water and not chewed or crushed to avoid the full dose entering the blood stream too quickly and increasing the risks of side effects.

Following a full medical appraisal, the doctor will decide which dose of Ionamin to prescribe and for how long. Typically the two strengths mean that the patient will be prescribed the 15mg dose initially and if this proves effective this lower dose can be maintained.

Where the patient shows limited responsiveness to 15mg, the doctor can prescribe the higher 30mg dose. Considering the potential risks and side effects of taking phentermine, the lower dose of Ionamin offers an opportunity of seeing if a milder dose is effective which reduces any associated risks.

Conditions of Prescription

Ionamin is approved by the FDA for the treatment of short term obesity in patients who have a BMI of over 30, or a BMI of 27 where there are weight related risks of hypertension, diabetes, hyperlipidemia.

Like Adipex P it is intended to be accompanied by a lifestyle plan which incorporates healthy eating and exercise to build on the results achieved by the diet drug.

Ionamin is not suitable for those with cardiovascular, kidney, liver, blood vessel disease, diabetes, thyroid, anxiety, arteriosclerosis or hypertension, the pregnant or nursing. Those with alcohol or drug dependency are unsuitable for Ionamin because of its habit forming nature.

Unlike Adipex P which cannot be prescribed to the under 17s, Ionamin is suitable for adolescents aged 12 and above, which could prove effective in treating the growing problem of childhood obesity.

Risks of complication associated with other medications should be established through a thorough medical consultation, other weight loss drugs, MAO inhibitors and SSRIs for depression, asthma, sinus and insulin medications are known to cause adverse reactions when taken with Ionamin.

Continued Medical Supervision

In common with all phentermine drugs the patient will be monitored by their doctor to assess its suitability and effectiveness.

The patient is advised to report any unpleasant side effects from taking the drug, and the length of treatment and method of stopping the course will be managed to avoid tolerance and withdrawal. Unlike Adipex P, the lower strength of Ionamin does at least mean that withdrawal might be less of an issue for the patient.

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How long should I take Phentermine for?

Can taking Phentermine long term cause unwanted side effects and even addiction?

woman-taking-phentermineTaking phentermine for too long can cause serious risks to health and can become addictive, so both the dose and duration of treatment can only be assessed safely following a thorough medical consultation.

Length of Treatment Considerations

Doctors will determine the length of treatment based on the patient’s age, weight, medical condition and background. Due to its habit forming nature and potential side effects the length of treatment will vary from person to person.

As it is only prescribed for short term treatment of obesity to mobilize initial weight loss which should then be continued through diet and exercise, the length of treatment cannot exceed 12 weeks.

Typically, phentermine is prescribed for a period of 3-6 weeks, but in some cases just a few days or for the full 12 weeks. During the course the doctor will monitor the effects of the drug on the individual, taking into account how their body reacts and how effective the treatment is and at any time the doctor can alter the course.

Risks of Long Term Use

As phentermine is pharmaceutically similar to amphetamine, long term use can lead to addiction. It is also known that over time the body builds a tolerance to it so its appetite suppressing qualities are only effective over a short period of time.

Taking phentermine for longer periods will not aid further weight loss but just lead to serious health risks. The end of the course needs strict medical control as it is common to experience symptoms of withdrawal when phentermine is stopped due to its habit forming nature.

Common side effects whilst taking the drug and even coming off it include insomnia, diarrhoea and hypertension. Prolonged use can lead to cardiovascular problems as well as life threatening allergies and central nervous system complications.

The Right Dosage

woman-taking-phentermine-dosagePhentermine is available in 15, 30 and 37.5mg doses, in immediate release formulas which are absorbed quickly into the blood stream, and time release formulas which are typically released more slowly over a period of 8-12 hours.

The dose and form will be assessed by the doctor and prescribed according to the patient’s individual circumstances.

Phentermine can create a 5-10% loss of initial body weight, this can be potentially lifesaving for the medically obese who have been unable to lose weight and whose health is in jeopardy because of it.

Treatment with phentermine can be incredibly successful, but the right dose and course is vital in ensuring weight loss is achieved safely and successfully.

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